动物寄生性蠕虫基因组学研究进展

doi:10.11843/j.issn.0366-6964.2017.06.002

摘要/Abstract

摘要：

动物（人）寄生性蠕虫病主要由寄生性线虫、吸虫和绦虫引起，严重威胁着人和动物的健康，但目前尚无有效的防治措施。近年来，随着测序技术的不断发展，越来越多种类的寄生性蠕虫基因组序列被测定和解析，寄生性蠕虫的生物学特征也被更深层次地挖掘。本文中作者将就寄生性蠕虫全基因组测序现状、基因的组成及特征、功能基因组的研究等进行综述，为深入了解寄生性蠕虫的起源、进化和致病机制，以及为寄生性蠕虫病的诊断、新药设计和疫苗研发提供新的思路。

Abstract:

Animal (human) parasitic helminthiases are mainly caused by parasitic nematodes, trematodes and cestodes,which are seriously threat to human and animal health, but there are no effective prevent and control measures at the current time. With the rapid development of genome sequencing technology in recent years, increasing numbers of parasitic helminth genomes have been sequenced, the biological characteristics of helminth parasite were deeply analyzed. This paper reviews the present situation of the whole genome sequencing of parasitic helminth, the composition and characteristics of the genomes and the advancement in functional genomics, which will provide the base-data for study of the evolution and pathogenic mechanism of parasitic helminth, and for development of diagnostic methods, new medicines and vaccines for parasitic helminthiasis.

中图分类号:

S852.73

杨洋, 付宝权. 动物寄生性蠕虫基因组学研究进展[J]. 畜牧兽医学报, 2017, 48(6): 979-989.

YANG Yang, FU Bao-quan. Advances on Animal Parasitic Helminth Genomics[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(6): 979-989.

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